Pancreatic cancer is associated with poor prognosis, making early and accurate diagnosis critical. However, benign or inflammatory pancreatic conditions such as autoimmune pancreatitis, focal pancreatitis, and cystic lesions can mimic malignancy on imaging. This article reviews CT and MRI features that help differentiate pancreatic adenocarcinoma from its mimics. Imaging findings such as ductal obstruction, vascular involvement, delayed enhancement, and diffusion restriction are discussed in detail. Case-based examples illustrate pitfalls and strategies for accurate interpretation. The review emphasizes a multimodal approach combining imaging, clinical history, and laboratory findings to minimize misdiagnosis and guide optimal management.

Keywords: Pancreatic Cancer, Mimicking Lesions, CT Imaging, MRI Imaging, Differential Diagnosis